Attentional Bias, Pupillometry, and Spontaneous Blink Rate: Eye Characteristic Assessment Within a Translatable Nicotine Cue Virtual Reality Paradigm. JMIR Serious Games. 2024 Jun 27; 12:e54220. Courtney KE, Liu W, Andrade G, Schulze J, Doran N. PMID: 38952012; PMCID: PMC11220568.
A preliminary investigation of physical and mental health features of cannabis & nicotine co-use among adolescents and young adults by sex. Addict Behav. 2024 09; 156:108064. Wallace AL, Courtney KE, Wade NE, Doran N, Delfel EL, Baca R, Hatz LE, Thompson C, Andrade G, Jacobus J. PMID: 38821010.
Investigating sex differences and age of onset in emotion regulation, executive functioning, and cannabis use in adolescents and young adults. J Cannabis Res. 2024 Apr 26; 6(1):20. Wade NE, Courtney KE, Wallace AL, Hatz L, Jacobus J. PMID: 38671541; PMCID: PMC11046960.
Parameter Space and Potential for Biomarker Development in 25 Years of fMRI Drug Cue Reactivity: A Systematic Review. JAMA Psychiatry. 2024 Apr 01; 81(4):414-425. Addiction Cue-Reactivity Initiative (ACRI) Network, Sangchooli A, Zare-Bidoky M, Fathi Jouzdani A, Schacht J, Bjork JM, Claus ED, Prisciandaro JJ, Wilson SJ, Wüstenberg T, Potvin S, Ahmadi P, Bach P, Baldacchino A, Beck A, Brady KT, Brewer JA, Childress AR, Courtney KE, Ebrahimi M, Filbey FM, Garavan H, Ghahremani DG, Goldstein RZ, Goudriaan AE, Grodin EN, Hanlon CA, Haugg A, Heilig M, Heinz A, Holczer A, Van Holst RJ, Joseph JE, Juliano AC, Kaufman MJ, Kiefer F, Khojasteh Zonoozi A, Kuplicki RT, Leyton M, London ED, Mackey S, McClernon FJ, Mellick WH, Morley K, Noori HR, Oghabian MA, Oliver JA, Owens M, Paulus MP, Perini I, Rafei P, Ray LA, Sinha R, Smolka MN, Soleimani G, Spanagel R, Steele VR, Tapert SF, Vollstädt-Klein S, Wetherill RR, Witkiewitz K, Yuan K, Zhang X, Verdejo-Garcia A, Potenza MN, Janes AC, Kober H, Zilverstand A, Ekhtiari H. PMID: 38324323; PMCID: PMC11304510.
Neurite Orientation Dispersion and Density Imaging (NODDI) of Brain Microstructure in Adolescent Cannabis and Nicotine Use. Behav Sci (Basel). 2024 Mar 13; 14(3). Wallace AL, Courtney KE, Wade NE, Hatz LE, Baca R, Jacobson A, Liu TT, Jacobus J. PMID: 38540534; PMCID: PMC10968201.
The Combined Effects of Nicotine and Cannabis on Cortical Thickness Estimates in Adolescents and Emerging Adults. Brain Sci. 2024 Feb 21; 14(3). Hernandez Mejia M, Courtney KE, Wade NE, Wallace A, Baca RE, Shen Q, Happer JP, Jacobus J. PMID: 38539584; PMCID: PMC10967898.
Traumatic brain injury, working memory-related neural processing, and alcohol experimentation behaviors in youth from the ABCD cohort. Dev Cogn Neurosci. 2024 Apr; 66:101344. Delfel EL, Aguinaldo L, Correa K, Courtney KE, Max JE, Tapert SF, Jacobus J. PMID: 38277713; PMCID: PMC10832371.
First Used Nicotine/Cannabis Product and Associated Outcomes in Late Adolescents. Subst Use Misuse. 2024; 59(5):699-706. Hatz LE, Courtney KE, Wade NE, Thompson C, Baca R, Andrade G, Doran N, Jacobus J. PMID: 38170177; PMCID: PMC10923017.
Evaluation of Gaze-to-Object Mapping Algorithms for Use in "Real-World" Translatable Neuropsychological Paradigms. Psychol Neurosci. 2023 Dec; 16(4):339-348. Liu W, Andrade G, Schulze J, Courtney KE. PMID: 38298524; PMCID: PMC10827330.
The effects of nicotine use during adolescence and young adulthood on gray matter cerebral blood flow estimates. Brain Imaging Behav. 2024 Feb; 18(1):34-43. Courtney KE, Baca R, Thompson C, Andrade G, Doran N, Jacobson A, Liu TT, Jacobus J. PMID: 37851272; PMCID: PMC10844445.
Associations between nicotine product use and craving among stable daily and non-daily users. Addict Behav. 2023 Jul 06; 146:107803. Reed BW, Doran N, Courtney KE. PMID: 37423069.
Application of the RDoC Framework to Predict Alcohol Use and Suicidal Thoughts and Behaviors among Early Adolescents in the Adolescent Brain and Cognitive Development (ABCD) Study. Brain Sci. 2022 Jul 17; 12(7). Aguinaldo LD, Coronado C, Gomes DA, Courtney KE, Jacobus J. PMID: 35884741; PMCID: PMC9315509.
Young Adult E-Cigarette and Combustible Tobacco Users Attitudes, Substance Use Behaviors, Mental Health, and Neurocognitive Performance. Brain Sci. 2022 Jul 06; 12(7). Wade NE, Courtney KE, Doran N, Baca R, Aguinaldo LD, Thompson C, Finegan J, Jacobus J. PMID: 35884696; PMCID: PMC9312928.
White matter integrity in adolescent irritability: A preliminary study. Psychiatry Res Neuroimaging. 203422 08; 324:111491. Hodgdon EA, Courtney KE, Yan M, Yang R, Alam T, Walker JC, Yu Q, Takarae Y, Cordeiro Menacho V, Jacobus J, Wiggins JL. PMID: 35635933; PMCID: PMC9676048.
The Effects of Nicotine and Cannabis Co-Use During Late Adolescence on White Matter Fiber Tract Microstructure. J Stud Alcohol Drugs. 2022 03; 83(2):287-295. Courtney KE, Sorg S, Baca R, Doran N, Jacobson A, Liu TT, Jacobus J. PMID: 35254252; PMCID: PMC8909919.
Using Virtual Reality to Induce and Assess Objective Correlates of Nicotine Craving: Paradigm Development Study. JMIR Serious Games. 2022 Feb 15; 10(1):e32243. Liu W, Andrade G, Schulze J, Doran N, Courtney KE. PMID: 35166685; PMCID: PMC8889474.
A methodological checklist for fMRI drug cue reactivity studies: development and expert consensus. Nat Protoc. 2022 03; 17(3):567-595. Ekhtiari H, Zare-Bidoky M, Sangchooli A, Janes AC, Kaufman MJ, Oliver JA, Prisciandaro JJ, Wüstenberg T, Anton RF, Bach P, Baldacchino A, Beck A, Bjork JM, Brewer J, Childress AR, Claus ED, Courtney KE, Ebrahimi M, Filbey FM, Ghahremani DG, Azbari PG, Goldstein RZ, Goudriaan AE, Grodin EN, Hamilton JP, Hanlon CA, Hassani-Abharian P, Heinz A, Joseph JE, Kiefer F, Zonoozi AK, Kober H, Kuplicki R, Li Q, London ED, McClernon J, Noori HR, Owens MM, Paulus MP, Perini I, Potenza M, Potvin S, Ray L, Schacht JP, Seo D, Sinha R, Smolka MN, Spanagel R, Steele VR, Stein EA, Steins-Loeber S, Tapert SF, Verdejo-Garcia A, Vollstädt-Klein S, Wetherill RR, Wilson SJ, Witkiewitz K, Yuan K, Zhang X, Zilverstand A. PMID: 35121856; PMCID: PMC9063851.
Preliminary Evidence for Cannabis and Nicotine Urinary Metabolites as Predictors of Verbal Memory Performance and Learning Among Young Adults. J Int Neuropsychol Soc. 2021 07; 27(6):546-558. Wade NE, Baca R, Courtney KE, McCabe CJ, Infante MA, Huestis MA, Jacobus J. PMID: 34261558; PMCID: PMC8288450.
The Relationship between Early Alcohol Use Behaviors and Adolescent Pubertal and Psychosocial Development: A Latent Growth Analysis. Subst Use Misuse. 2021; 56(6):861-870. May AC, Aguinaldo LD, Tan R, Courtney KE, Jacobus J. PMID: 33754935; PMCID: PMC8118223.
The effects of nicotine and cannabis co-use during adolescence and young adulthood on white matter cerebral blood flow estimates. Psychopharmacology (Berl). 2020 Dec; 237(12):3615-3624. Courtney KE, Baca R, Doran N, Jacobson A, Liu TT, Jacobus J. PMID: 32803367; PMCID: PMC7686080.
Executive function moderates naltrexone effects on methamphetamine-induced craving and subjective responses. Am J Drug Alcohol Abuse. 2020 09 02; 46(5):565-576. Lim AC, Grodin EN, Green R, Venegas A, Meredith LR, Courtney KE, Moallem NR, Sayegh P, London ED, Ray LA. PMID: 32343625; PMCID: PMC7920534.
Courtney KE, Infante MA, Bordyug M, Simmons AN, Tapert SF. Prospective Associations between BOLD Markers of Response Inhibition and the Transition to Frequent Binge Drinking. Alcohol Clin Exp Res. 2020 Jan 06. PMID: 31904873.View in: PubMed
Infante MA, Nguyen-Louie TT, Worley M, Courtney KE, Coronado C, Jacobus J. Neuropsychological Trajectories Associated with Adolescent Alcohol and Cannabis Use: A Prospective 14-Year Study. J Int Neuropsychol Soc. 2019 Dec 11; 1-12. PMID: 31822320.View in: PubMed
Courtney KE, Li I, Tapert SF. The effect of alcohol use on neuroimaging correlates of cognitive and emotional processing in human adolescence. Neuropsychology. 2019 Sep; 33(6):781-794. PMID: 31448946.View in: PubMed
Jacobus J, Courtney KE, Hodgdon EA, Baca R. Cannabis and the developing brain: What does the evidence say? Birth Defects Res. 2019 10 15; 111(17):1302-1307. PMID: 31385460.View in: PubMed
Lim AC, Ghahremani DG, Grodin EN, Green R, Bujarski S, Hartwell EE, Courtney KE, Hutchison K, Miotto K, Ray LA. Neuroimaging findings from an experimental pharmacology trial of naltrexone in heavy drinkers of East Asian descent. Drug Alcohol Depend. 2019 07 01; 200:181-190. PMID: 31160146.View in: PubMed
Courtney KE, Infante MA, Brown GG, Tapert SF, Simmons AN, Smith TL, Schuckit MA. The Relationship Between Regional Cerebral Blood Flow Estimates and Alcohol Problems at 5-Year Follow-Up: The Role of Level of Response. Alcohol Clin Exp Res. 2019 05; 43(5):812-821. PMID: 30924954.View in: PubMed
Grodin EN, Courtney KE, Ray LA. Drug-Induced Craving for Methamphetamine Is Associated With Neural Methamphetamine Cue Reactivity. J Stud Alcohol Drugs. 2019 03; 80(2):245-251. PMID: 31014470.View in: PubMed
Infante MA, Courtney KE, Castro N, Squeglia LM, Jacobus J. Adolescent Brain Surface Area Pre- and Post-Cannabis and Alcohol Initiation. J Stud Alcohol Drugs. 2018 11; 79(6):835-843. PMID: 30573013.View in: PubMed
Lim AC, Courtney KE, Moallem NR, Allen VC, Leventhal AM, Ray LA. A Brief Smoking Cessation Intervention for Heavy Drinking Smokers: Treatment Feasibility and Acceptability. Front Psychiatry. 2018; 9:362. PMID: 30147661.View in: PubMed
Frontoinsular involvement is important for successful inhibition and cognitive control. Altered brain activation during response inhibition may allow for impulse regulation difficulties due to alcohol consumption. This can be used to inform and optimize interventions aimed at preventing the escalation of youth who already began drinking.
The results of this study provide the first evidence of naltrexone-induced changes in BOLD measures of methamphetamine cue-induced craving. Functional connectivity with the nucleus accumbens was not found to be modulated by naltrexone, and instead the results suggest that naltrexone may be functioning to reduce the salience of the methamphetamine cues by reducing sensorimotor processing and integration, and by engaging greater frontal regulation of salience attribution via dopaminergic, glutamatergic, and/or GABAergic pathways linking the dorsal striatum, midbrain, and precuneus to frontal, dorsal striatal, and sensorimotor regions during methamphetamine cue processing. The knowledge of these neurobiological pathways may prove to be useful in the prediction of clinical outcomes and aid in the development and application of medications such as naltrexone for the treatment of methamphetamine use disorders.